Tommy Pickles - Elizabeth Daily
Chuckie Finster - Christine Cavanaugh
Phil Deville - Kath Soucie
Lil Deville - Kath Soucie
Dil Pickles - Tara Strong
Angelica Pickles - Cheryl Chase
Susie Carmichael - Cree Summer

Didi Pickles - Melanie Chartoff
Stu Pickles - Jack Riley
Chaz Finster - Michael Bell
Betty Deville - Kath Soucie
Howard Deville - Phil Proctor
Drew Pickles - Michael Bell
Charlotte Pickles - Tress MacNeille
Dr. Lucy Carmichael - Hattie Winston

Grandpa Lou Pickles - Joe Alaskey
Boris Kerpacketer - Michael Bell
Minka Kerpacketer - Melanie Chartoff
Aunt Mirium - Andrea Maryin

Dr. Lipshitz - Tony Jay
Rex Pester - Tim Curry
Reptar Wagon - Busta Rhymes
Ranger Frank - David Spade
Ranger Margaret - Whoopi Goldberg
Lt. Klavin - Margaret Cho
Nurse - Edie McChung
Circus TV announcer - Gregg Berger
Igor - Phil Proctor
Serge - Abraham Benrubi

Newborn Baby - Laurie Anderson
Newborn Baby - Beck
Newborn Baby - Louis Freese
Newborn Baby - Jakob Dylan
Newborn Baby - Phife Dawg
Newborn Baby - Gordon Gano
Newborn Baby - Iggy Pop
Newborn Baby - Lenny Kravitz
Newborn Baby - Lisa Loeb
Newborn Baby - Lou Rawls
Newborn Baby - Patti Smith
Newborn Baby - Dawn Robinson
Newborn Baby - Fred Schneider
Newborn Baby - Kate Pierson
Newborn Baby - Cindy Wilson